General Cell Lines and Cell Cultures
ATCC Hathewaya histolytica
Bacterial type strain with applications in quality control testing or as a control strain for anaerobe identification.
ATCC NCI-H2052; Mesothelioma; Human (Homo sapiens)
NCI-H2052 [H2052] is a cell line exhibiting epithelial morphology that was isolated from the lungs of a 65-year-old, White, male patient with stage 4 mesothelioma. This product has applications in cancer research.
ATCC CT26.CL25; Colon Carcinoma; Mouse (Mus musculus)
CT26.CL25 is a cell line exhibiting fibroblast-like morphology that was isolated from the large intestine of a mouse with undifferentiated colon carcinoma. This cell line was deposited by N Restifo and can be used in cancer research.
ATCC K562-s; Chronic myeloid leukemia ; Human (Homo sapiens)
K56S-s is a cell line with hematopoietic morphology that was isolated in 1999 from the bone marrow of a 53-year-old female with chronic myeloid leukemia at blast crisis. The paired K562-s and K562-r clones are useful cell line models of sensitivity and resistance to a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia. It has applications in immune system disorder research.
Eurofins Discoverx cAMP Hunter CHO-K1 C5R1 Gi Cell Line, 2 vials. (95-0079C2)
The cAMP Hunter C5R1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. complement C5a) based activation of C5R1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type C5R1, a naturally Gi/Go coupled GPCR. Upon activation of C5R1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Staphylococcus aureus; subsp. aureus
Staphylococcus aureus subsp. aureus strain FDA is used in sterility testing and susceptibility disc testing. This strain is recommended as a test organism for USP <81>.
STEMCELL Technologies Human Peripheral Blood Leukopak, Fresh, Size: 5 x 10^9 cells minimum
Obtain large numbers of single-donor mononuclear cells (PBMCs) from normal peripheral blood and reduce the time and reagents required for your downstream cell isolation. Enjoy personalized service, custom products, flexible delivery times, and multiple size options. Leukopaks are highly concentrated, low-volume apheresis collections from normal donors, with Institutional Review Board (IRB)-approved consent forms and protocols. Each full-sized leukopak is produced from ~2 - 3x blood volumes using the Spectra Optia Apheresis System (unless otherwise requested), with ACDA as the anticoagulant. High-resolution HLA typing (Class I and Class II alleles and CMV status) are available upon request. Contact techsupport@stemcell.com for more information, including donor selection or information (BMI category, smoking status, ethnicity, etc.). Donors are recallable and are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C. Certain products are only available in select territories.
Cell Biologics Rat Primary Dermal Fibroblasts, Frozen Vial
Rat Primary Dermal Fibroblasts can be used in assays of standard biochemical procedures performed with cell cultures include RT-PCR, Western blotting, immunoprecipitation, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.
Eurofins Discoverx PathHunter U2OS IL23R/IL12RB1 Dimerization Cell Line, 2 vials. (93-1007C3)
The PathHunter IL23R/IL12RB1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-23) induced dimerization of IL23R/IL12RB1 receptors. This product uses EFC technology. The cell line included overexpresses IL23R target protein fused to PK alongside IL12RB1 target protein fused to EA. Upon ligand-induced dimerization of IL23R/IL12RB1, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter U2OS FGFR4 Functional Assay, 2 vials. (93-1022C3)
The PathHunter U2OS FGFR4 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated FGFR4 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged FGFR4 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter HEK 293 cyno CXCR2 β-Arrestin Cell Line, 2 vials. (93-0981C1)
The PathHunter cyno CXCR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno CXCR2 and EA-tagged β-Arrestin-2. Activation of CXCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Cynomolgus monkey version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Angio Proteomie HUMAN PLACENTAL MICROVASCULAR
HPlMVPCs (cAP-0029) are isolated from normal human placental tissue. The cells are shipped in frozen vials (the cells are provided @ passage 3).
ATCC HCT116-SLC25A46-KO-c11; Colorectal carcinoma; Human (Homo sapiens)
The HCT116-SLC25A46-KO-c11 cell line contains a -19 deletion/-10 deletion in SLC25A46 gene and combined with the parental cell line and other HCT116 derivatives can be used in cancer drug screening.
Eurofins Discoverx PathHunter CHO-K1 mRXFP4 β-Arrestin Cell Line, 2 vials. (93-0929C2)
The PathHunter mRXFP4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. insulin-like 5, relaxin-3) based activation of mRXFP4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mRXFP4 and EA-tagged β-Arrestin-2. Activation of mRXFP4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.